WASHINGTON (AP) — Secretary of State Antony Blinken will travel to China this coming week as Washington and Beijing try to keep ties on an even keel despite major differences on issues from the path to peace in the Middle East to the supply of synthetic opioids that have heightened fears over global stability.

The rivals are at odds on numerous fronts, including Russia’s war in Ukraine, Taiwan and the South China Sea, North Korea, Hong Kong, human rights and the detention of American citizens. The United States and China also are battling over trade and commerce issues, with President Joe Biden announcing new tariffs on imports of Chinese steel this past week.

The State Department said Saturday that Blinken, on his second visit to China in less than a year, will travel to Shanghai and Beijing starting Wednesday for three days of meetings with senior Chinese officials, including Foreign Minister Wang Yi. Talks between Blinken and Chinese President Xi Jinping are expected, although neither side will confirm such a meeting is happening until shortly before it takes place.